CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment.

ABSTRACT:

Background

Early dissemination to distant organs accounts for the dismal prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). Chronic, dysregulated, persistent and unresolved inflammation provides a preferred tumor microenvironment (TME) for tumorigenesis, development, and metastasis. A better understanding of the key regulators that maintain inflammatory TME and the development of predictive biomarkers to identify patients who are most likely to benefit from specific inflammatory-targeted therapies is crucial for advancing personalized cancer treatment.

Methods

This study identified cell-specific expression of CALB2 in human PDAC through single-cell RNA sequencing analysis and assessed its clinicopathological correlations in tissue microarray using multi-colo

SUBMITTER: Tao J 

PROVIDER: S-EPMC11448066 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature