Nuclear reorganization by NPM1-mediated phase separation triggered by adenovirus core protein VII.

ABSTRACT: Recent evidence has revealed that the reorganization of nuclear domains is largely mediated by liquid-liquid phase separation (LLPS). During viral infection, numerous nuclear domains undergo significant changes through LLPS for and against the replication of the virus. However, the regulatory mechanism of LLPS in response to viral infection and its detailed functions in viral replication remain unclear. In this study, we found that the activity of the nucleolar protein NPM1, a remodeling factor for the chromatin-like structure of adenovirus DNA, to induce LLPS is required for deposition of adenovirus core protein VII in a subnuclear domain, the virus-induced post-replication (ViPR) body, in the late phases of infection. The interaction between NPM1 and protein VII was responsible for initi

SUBMITTER: Genoveso MJ 

PROVIDER: S-EPMC11448090 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature