Calcium-binding protein TgpCaBP regulates calcium storage of the zoonotic parasite <i>Toxoplasma gondii</i>.

ABSTRACT: Toxoplasma gondii, the causative parasite of toxoplasmosis, is an apicomplexan parasite that infects warm-blooded mammals. The ability of the calcium-binding proteins (CBPs) to transport large amounts of Ca²⁺ appears to be critical for the biological activity of T. gondii. However, the functions of some members of the CBP family have not yet been deciphered. Here, we characterized a putative CBP of T. gondii, TgpCaBP (TGME49_229480), which is composed of four EF-hand motifs with Ca²⁺-binding capability. TgpCaBP was localized in the cytosol and ER of T. gondii, and parasites lacking the TgpCaBP gene exhibited diminished abilities in cell invasion, intracellular growth, egress, and motility. These phenomena were due to the abnormalitie

SUBMITTER: Sun W 

PROVIDER: S-EPMC11448132 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature