Hetero-antagonism of avibactam and sulbactam with cefiderocol in carbapenem-resistant <i>Acinetobacter</i> spp.

ABSTRACT: Cefiderocol, a siderophore-cephalosporine conjugate antibiotic, shows promise as a therapeutic option for carbapenem-resistant (CR) Acinetobacter infections. While resistance has already been reported in A. baumannii, combination therapies with avibactam or sulbactam reduce MICs of cefiderocol, extending its efficacy. However, careful consideration is necessary when using these combinations. In our experiments, exposure of A. baumannii and A. lwoffii to cefiderocol and sulbactam or avibactam led to the selection of cefiderocol-resistant strains. Three of those were subjected to whole genome sequencing and transcriptomic analysis. The strains all possessed synonymous and non-synonymous substitutions and short deletions. The most significant mutations affected eff

SUBMITTER: Wong O 

PROVIDER: S-EPMC11448186 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature