Dobutamine stress echocardiography after positive CCTA: diagnostic performance using fractional flow reserve and instantaneous wave-free ratio as reference standards.

ABSTRACT:

Aims

To assess the diagnostic accuracy of dobutamine stress echocardiography (DSE) in symptomatic patients with a low to intermediate pretest probability of obstructive coronary artery disease (CAD) and a positive coronary CT angiography (CCTA).

Methods

We prospectively enrolled 104 consecutive patients undergoing coronary angiography for symptoms of stable CAD and a CCTA indicative of obstructive CAD. The diagnostic performance of DSE was evaluated against two intracoronary pressure indices: (a) fractional flow reserve (FFR) with a cut-off of ≤0.80 and (b) instantaneous wave-free ratio (iFR) with a cut-off of ≤0.89, indicating haemodynamically significant stenoses.

Results

Of 102 patients, 46 (45%) had at least one significant lesion as defined by FFR, as did 37 (36%

SUBMITTER: Tjellaug Braten A 

PROVIDER: S-EPMC11448196 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature