Dancing with disorder: chorea - an unusual and neglected manifestation of antiphospholipid syndrome.

ABSTRACT:

Objectives

Chorea, characterised by involuntary, irregular movements, is a rare neurological manifestation of antiphospholipid syndrome (APS). The specific clinical features remain unclear. This study aimed to summarise the available evidence on antiphospholipid antibody (aPL)-associated chorea.

Methods

We used a mixed-methods approach, combining data from patients with chorea with aPL positivity admitted to Peking Union Medical College Hospital (PUMCH) from 2014 to 2024, with cases identified in public databases since 1983. We collected and analysed clinical, laboratory, and imaging results, along with their treatments and outcomes.

Results

A total of 180 patients with incident aPL-associated chorea were included (13 from PUMCH and 167 from the literature). The major

SUBMITTER: Hu S 

PROVIDER: S-EPMC11448224 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature