The role of exopolysaccharides Psl and Pel in resistance of <i>Pseudomonas aeruginosa</i> to the oxidative stressors sodium hypochlorite and hydrogen peroxide.

ABSTRACT: Pseudomonas aeruginosa is well-known for its antimicrobial resistance and the ability to survive in harsh environmental conditions due to an abundance of resistance mechanisms, including the formation of biofilms and the production of exopolysaccharides. Exopolysaccharides are among the major components of the extracellular matrix in biofilms and aggregates of P. aeruginosa. Although their contribution to antibiotic resistance has been previously shown, their roles in resistance to oxidative stressors remain largely elusive. Here, we studied the function of the exopolysaccharides Psl and Pel in the resistance of P. aeruginosa to the commonly used disinfectants and strong oxidizing agents NaOCl and H₂O₂. We observed that the simultaneous inactivati

SUBMITTER: da Cruz Nizer WS 

PROVIDER: S-EPMC11448232 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature