Mediation-adjusted multivariable Mendelian randomisation study identified novel metabolites related to mental health.

ABSTRACT:

Background

From the pathway perspective, metabolites have the potential to improve knowledge about the aetiology of psychiatric diseases. Previous studies suggested a link between specific blood metabolites and mental disorders, but some Mendelian randomisation (MR) studies in particular are insufficient for various reasons.

Objective

This study focused on bias assessment due to interdependencies between metabolites and psychiatric mediation effects.

Methods

In a multistep framework containing network and multivariable MR, direct effects of 21 mutually adjusted metabolites on 8 psychiatric disorders were estimated based on summary statistics of genome-wide association studies from multiple resources. Robust inverse-variance weighted models were used in primary analyse

SUBMITTER: Freuer D 

PROVIDER: S-EPMC11448235 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature