Emergence of a novel sequence type carbapenem-resistant hypervirulent <i>Klebsiella pneumoniae</i> ST6417 harboring <i>bla</i>_NDM-5 on the lncX3 plasmid.

ABSTRACT: Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a significant pathogen causing major public health problems worldwide. This study characterized a novel sequence type 6417 (ST6471) CR-hvKP strain recovered from the blood of a male patient with septicemia. Strain CR2021 is not susceptible to carbapenems, cephalosporin, sulfonamides, quinolones, or levofloxacin and is susceptible to amikacin and tigecycline. Molecular typing indicated that ST6417 is derived from the most dominant hypervirulent K. pneumoniae (hvKP) clone in China, ST23, with a single-locus variation in tonB. The genomic characterization of CR2021, which contains three plasmids, was performed through whole-genome sequencing. The plasmid pCR2021_IncFII contains 12 antibiotic resistance

SUBMITTER: Liu J 

PROVIDER: S-EPMC11448260 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature