Transcriptional regulators <i>SP110</i> and <i>SP140</i> modulate inflammatory response genes in <i>Mycobacterium tuberculosis</i>-infected human macrophages.

ABSTRACT: Understanding the functions of human transcriptional regulatory genes SP110 and SP140 during Mycobacterium tuberculosis infection is crucial; in a mouse model, homologous genes Sp110 and Sp140 have been shown to negatively regulate inflammatory response genes, including the type I interferon (IFN) response. The reduction of these genes in mice is associated with susceptibility to M. tuberculosis infection and the development of necrotizing granulomatous lesions. To investigate the involvement of SP110 and SP140 in human inflammatory response, we analyzed their regulatory manner in THP-1 macrophages infected with M. tuberculosis. Genome-wide transcriptional profiling revealed that the depletion of SP110 and/or SP140

SUBMITTER: Nakamura H 

PROVIDER: S-EPMC11448263 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature