Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tumor subtypes, known as 'basal-like' and 'classical' subtypes are associated with differences in metabolic gene expression including genes involved in glycolysis. Tumor subtype-specific metabolism phenotypes may provide new targets for treatment development in PDAC, but their functional relevance has not been fully elucidated. We aimed to investigate differences in metabolic profiles and transcriptomes in tumor models derived from patients with basal-like and classical tumors.

Methods

Patient-derived organoids (PDOs) were established from

SUBMITTER: Ali HA 

PROVIDER: S-EPMC11448267 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature