Brain Iron in signature regions relating to cognitive aging in older adults: the Taizhou Imaging Study.

ABSTRACT:

Background

Recent magnetic resonance imaging (MRI) studies have established that brain iron accumulation might accelerate cognitive decline in Alzheimer's disease (AD) patients. Both normal aging and AD are associated with cerebral atrophy in specific regions. However, no studies have investigated aging- and AD-selective iron deposition-related cognitive changes during normal aging. Here, we applied quantitative susceptibility mapping (QSM) to detect iron levels in cortical signature regions and assessed the relationships among iron, atrophy, and cognitive changes in older adults.

Methods

In this Taizhou Imaging Study, 770 older adults (mean age 62.0 ± 4.93 years, 57.5% women) underwent brain MRI to measure brain iron and atrophy, of whom 219 underwent neuropsychological tes

SUBMITTER: Li R 

PROVIDER: S-EPMC11448274 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature