Smaller cornu ammonis (CA3) as a potential risk factor for suicidal behavior in mood disorders.

ABSTRACT: Mood disorders and suicidal behavior have moderate heritability and familial transmission, and are associated with smaller hippocampal volumes. However, it is unclear whether hippocampal alterations reflect heritable risk or epigenetic effects of childhood adversity, compensatory mechanisms, illness-related changes, or treatment effects. We sought to separate the relationships of hippocampal substructure volumes to mood disorder, suicidal behavior, and risk and resilience to both by examining high familial risk individuals (HR) who have passed the age of greatest risk for psychopathology onset. Structural brain imaging and hippocampal substructure segmentation quantified Cornu Ammonis (CA1-4), dentate gyrus, and subiculum gray matter volumes in healthy volunteers (HV, N = 25) and three gro

SUBMITTER: Pantazatos SP 

PROVIDER: S-EPMC11448310 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature