Coexistence of plasmid-mediated tmexCD2-toprJ2, bla_IMP-4, and bla_NDM-1 in Klebsiella quasipneumoniae.

ABSTRACT: Klebsiella quasipneumoniae is a potential pathogen that has not been studied comprehensively. The emergence of multidrug-resistant (MDR) K. quasipneumoniae, specifically strains resistant to tigecycline and carbapenem, presents a significant challenge to clinical treatment. This investigation aimed to characterize MDR K. quasipneumoniae strain FK8966, co-carrying tmexCD2-toprJ2, bla_IMP-4, and bla_NDM-1 by plasmids. It was observed that FK8966's MDR was primarily because of the IncHI1B-like plasmid co-carrying tmexCD2-toprJ2 and bla_IMP-4, and an IncFIB(K)/IncFII(K) plasmid harboring bla_NDM-1. Furthermore, the phylogenetic analysis revealed that IncHI1B-like plasmids carrying tmexCD2-

SUBMITTER: Ma Z 

PROVIDER: S-EPMC11448383 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature