Lipid Rafts from Olfactory Ensheathing Cells: Molecular Composition and Possible Roles.

ABSTRACT: Olfactory ensheathing cells (OECs) are specialized glial cells of the olfactory system, believed to play a role in the continuous production of olfactory neurons and ensheathment of their axons. Although OECs are used in therapeutic applications, little is known about the cellular mechanisms underlying their migratory behavior. Recently, we showed that OEC migration is sensitive to ganglioside blockage through A2B5 and Jones antibody in OEC culture. Gangliosides are common components of lipid rafts, where they participate in several cellular mechanisms, including cell migration. Here, we characterized OEC lipid rafts, analyzing the presence of specific proteins and gangliosides that are commonly expressed in motile neural cells, such as young neurons, oligodendrocyte progenitors, and gliom

SUBMITTER: Campos FSO 

PROVIDER: S-EPMC11448638 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature