Cholecystectomy and risk of cardiovascular disease, all-cause and cause-specific mortality: a systematic review and updated meta-analysis.

ABSTRACT:

Objective

Questions remain about the association among cholecystectomy, cardiovascular disease, all-cause and cause-specific mortality. We performed a systematic review and meta-analysis to clarify these associations.

Methods

PubMed, Web of Science, Embase, and Cochrane Library databases were searched up to February 2024. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a DerSimonian-Laird random effects model.

Results

We screened 16,595 articles and included 14 studies. No significant association was found between cholecystectomy and cardiovascular disease (CVD), with RR being 1.03 (95% CI [0.77-1.37], p = 0.848, I ² = 99.6%), even in results with high heterogenous studies excluded (RR 1.20, 95% CI [0.97-1

SUBMITTER: Song Y 

PROVIDER: S-EPMC11448656 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature