A Balancing Act: The Immune System Supports Neurodegeneration and Neurogenesis.

ABSTRACT: Decapod crustaceans, like mammals, retain the ability to make new neurons throughout life. In mammals, immune cells are closely associated with stem cells that generate adult-born neurons. In crayfish, evidence suggests that immune cells (hemocytes) originating in the immune system travel to neurogenic regions and transform into neural progenitor cells. This nontraditional immune activity takes place continuously under normal physiological conditions, but little is known under pathological conditions (neurodegeneration). In this study, the immune system and its relationship with neurogenesis were investigated during neurodegeneration (unilateral antennular ablation) in adult crayfish. Our experiments show that after ablation (1) Proliferating cells decrease in neurogenic areas of the adult

SUBMITTER: Chaves da Silva PG 

PROVIDER: S-EPMC11448856 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature