Lanthanum Chloride Impairs Learning and Memory and Induces Dendritic Spine Abnormality by Down-Regulating Rac1/PAK Signaling Pathway in Hippocampus of Offspring Rats.

ABSTRACT: Lanthanum (La) is a natural rare earth element. It has neurotoxic effects which can impair learning and memory in humans. However, its mechanism of neurotoxicity is unclear. Learning and memory are coordinated by dendritic spines which form tiny protruding structures on the dendritic branches of neurons. This study investigated the effect of LaCl₃ exposure to pregnant and lactating rats on the offspring rats' learning and memory ability. In this study, rats were divided into 4 groups and given distilled water solution containing 0%, 0.125%, 0.25%, 0.5% LaCl₃, respectively, and this was done from conception to the end of the location. The effects of LaCl₃ on spatial learning and memory ability in offspring rats and in the development of dendritic spines in C

SUBMITTER: Sun W 

PROVIDER: S-EPMC11448949 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature