Cannabinoid CB₂ Receptor Modulation by the Transcription Factor NRF2 is Specific in Microglial Cells.

ABSTRACT: Nuclear factor erythroid 2-related factor 2 (NRF2) is a pleiotropic transcription factor that has neuroprotective and anti-inflammatory effects, regulating more than 250 genes. As NRF2, cannabinoid receptor type 2 (CB₂) is also implicated in the preservation of neurons against glia-driven inflammation. To this concern, little is known about the regulation pathways implicated in CB₂ receptor expression. In this study, we analyze whether NRF2 could modulate the transcription of CB₂ in neuronal and microglial cells. Bioinformatics analysis revealed an antioxidant response element in the promoter sequence of the CB₂ receptor gene. Further analysis by chemical and genetic manipulations of this transcription factor demonstrated that NRF2 is not able to

SUBMITTER: Galan-Ganga M 

PROVIDER: S-EPMC11449021 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature