Association of sarcopenia with severe chemotherapy toxicities and survival in patients with advanced gastric cancer.

ABSTRACT:

Background

Sarcopenia or skeletal muscle depletion is a poor prognostic factor for gastric cancer (GC). However, existing cutoff values of skeletal muscle index (SMI) for defining sarcopenia have been found to have limitations when clinically applied. This study aimed to determine the optimal cutoff for SMI to predict severe toxicities of chemotherapy and overall survival (OS) in patients with advanced GC.

Methods

Patients with metastatic gastric adenocarcinoma who received first-line palliative chemotherapy between January 2014 and December 2021 at Queen Mary Hospital, Hong Kong, were included in this study. The SMI was determined via a pre-chemotherapy computed tomography scan. Optimal cutoff points of SMI were identified by recursive partitioning analysis. Univariate and

SUBMITTER: Chan WL 

PROVIDER: S-EPMC11449055 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature