Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson's disease.

ABSTRACT: The ability to initiate volitional action is fundamental to human behaviour. Loss of dopaminergic neurons in Parkinson's disease is associated with impaired action initiation, also termed akinesia. Both dopamine and subthalamic deep brain stimulation (DBS) can alleviate akinesia, but the underlying mechanisms are unknown. An important question is whether dopamine and DBS facilitate de novo build-up of neural dynamics for motor execution or accelerate existing cortical movement initiation signals through shared modulatory circuit effects. Answering these questions can provide the foundation for new closed-loop neurotherapies with adaptive DBS, but the objectification of neural processing delays prior to performance of volitional action remains a significant challenge. To overcome this chall

SUBMITTER: Kohler RM 

PROVIDER: S-EPMC11449126 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature