Androgen Drives the Expression of SARS-CoV-2 Entry Proteins in Sinonasal Tissue.

ABSTRACT:

Background and objectives

Men have higher morbidity and mortality from COVID-19 than women, possibly due to androgen receptor-regulated viral entry protein expression. This led to a clinical trial of androgen deprivation therapy (ADT), which has not shown a significant benefit in the outcomes among hospitalized male COVID-19 patients. The aim of this study was to explore biological explanations for the failure of ADT to mitigate clinical outcomes in men with severe COVID-19 by assessing the role of androgen in regulating viral entry protein expression in the upper and lower respiratory tract.

Methods

Immunohistochemistry was used to assess the expression of transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) and how it correlated to androgen

SUBMITTER: Huang RR 

PROVIDER: S-EPMC11449218 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature