High blood eosinophils predict the risk of COPD exacerbation: A systematic review and meta-analysis.

ABSTRACT:

Background

The association between blood eosinophils and COPD exacerbation has been controversial. This study aims to investigate whether high blood eosinophils predict the risk of COPD exacerbation across different thresholds and subgroups.

Methods

PubMed, Embase and Web of science were searched for randomized controlled trial (RCT) and observational studies regarding the relationship between blood eosinophils and COPD exacerbation. Pooled risk ratio (RR) for COPD exacerbation was calculated using the Mantel-Haenszel method with a random-effects model.

Results

A total of 21 studies (1 RCT and 20 observational studies) with 79868 participants were included. Thresholds of high blood eosinophils including absolute counts (200, 300 and 400 cell/μL) and percentages (2%, 3

SUBMITTER: Chen F 

PROVIDER: S-EPMC11449345 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature