The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling.

ABSTRACT: Receptor tyrosine kinases such as EGF receptor (EGFR) stimulate phosphoinositide 3 kinases to convert phosphatidylinositol-4,5-bisphosophate [PtdIns(4,5)P₂] into phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P₃]. PtdIns(3,4,5)P₃ then remodels actin and gene expression, and boosts cell survival and proliferation. PtdIns(3,4,5)P₃ partly achieves these functions by triggering activation of the kinase Akt, which phosphorylates targets like Tsc2 and GSK3β. Consequently, unchecked upregulation of PtdIns(3,4,5)P₃-Akt signaling promotes tumor progression. Interestingly, 50-70% of PtdIns and PtdInsPs have stearate and arachidonate at sn-1 and sn-2 positions of glycerol, respectively, forming a species known as 38:4-PtdIns

SUBMITTER: Chan V 

PROVIDER: S-EPMC11449395 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature