Seminal plasma S100A8/A9 as a potential biomarker of genital tract inflammation.

ABSTRACT:

Abstract

Infections and inflammatory reactions in the male genital tract are the leading causes of male infertility with a prevalence of 6%-10%, primarily affecting testicular and epididymal function and ultimately compromising sperm quality. However, most infertile patients with genital infection/inflammation are asymptomatic and easily overlooked. Traditional indicators, including white blood cells, elastase, and other components in semen, can reflect inflammation of the genital tract, but there is still a lack of a uniform standard method of detection. Therefore, it is necessary to explore reliable markers in semen that reflect the inflammatory status of the genital tract. Using the experimental autoimmune orchitis (EAO) model to simulate noninfectious chronic orchitis, we succe

SUBMITTER: Shen QZ 

PROVIDER: S-EPMC11449414 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature