Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb.

ABSTRACT: The mandible plays an essential part in human life and, thus, defects in this structure can dramatically impair the quality of life in patients. Axolotls, unlike humans, are capable of regenerating their lower jaws; however, the underlying mechanisms and their similarities to those in limb regeneration are unknown. In this work, we used morphological, histological and transcriptomic approaches to analyze the regeneration of lateral resection defects in the axolotl mandible. We found that this structure can regenerate all missing tissues in 90 days through gap minimization, blastema formation and, finally, tissue growth, differentiation and integration. Moreover, transcriptomic comparisons of regenerating mandibles and limbs showed that they share molecular phases of regeneration, that thes

SUBMITTER: Kramer J 

PROVIDER: S-EPMC11449444 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature