A unique cell division protein critical for the assembly of the bacterial divisome.

ABSTRACT: Identification of unique essential bacterial genes is important for not only the understanding of their cell biology but also the development of new antimicrobials. Here, we report a previously unrecognized core component of the Acinetobacter baumannii divisome. Our results reveal that the protein, termed Aeg1 interacts with multiple cell division proteins, including FtsN, which is required for components of the divisome to localize to the midcell. We demonstrate that the FtsA_E202K and FtsB_E65A mutants effectively bypassed the need of Aeg1 by A. baumannii, as did the activation variants FtsW_M254I and FtsW_S274G. Our results suggest that Aeg1 is a cell division protein that arrives at the division site to initiate cell division by rec

SUBMITTER: Chu X 

PROVIDER: S-EPMC11449484 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature