An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis.

ABSTRACT: Endocrine disrupting chemicals (EDCs) such as bisphenol S (BPS) are xenobiotic compounds that can disrupt endocrine signaling due to steric similarities to endogenous hormones. EDCs have been shown to induce disruptions in normal epigenetic programming (epimutations) and differentially expressed genes (DEGs) that predispose disease states. Most interestingly, the prevalence of epimutations following exposure to many EDCs persists over multiple generations. Many studies have described direct and prolonged effects of EDC exposure in animal models, but many questions remain about molecular mechanisms by which EDC-induced epimutations are introduced or subsequently propagated, whether there are cell type-specific susceptibilities to the same EDC, and whether this correlates with differential e

SUBMITTER: Lehle JD 

PROVIDER: S-EPMC11449486 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature