Serum metabolomic profiling identifies potential biomarkers in arthritis in older adults: an exploratory study.

ABSTRACT:

Background

Seronegative elderly-onset rheumatoid arthritis (EORA)^neg and polymyalgia rheumatica (PMR) have similar clinical characteristics making them difficult to distinguish based on clinical features. We hypothesized that the study of serum metabolome could identify potential biomarkers of PMR vs. EORA^neg.

Methods

Arthritis in older adults (ARTIEL) is an observational prospective cohort with patients older than 60 years of age with newly diagnosed arthritis. Patients' blood samples were compared at baseline with 18 controls. A thorough clinical examination was conducted. A Bruker Avance 600 MHz spectrometer was used to acquire Nuclear Magnetic Resonance (NMR) spectra of serum samples. Chenomx NMR suite 8.5 was used for metabolite identification and

SUBMITTER: Cedeno M 

PROVIDER: S-EPMC11449491 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature