Heavy smoking increases early mortality risk in patients with hepatocellular carcinoma after curative treatment.

ABSTRACT:

Backgrounds/aims

Although cigarette smoking has been associated with an increased risk of hepatocellular carcinoma (HCC), its association with HCC mortality remains underexplored. We aimed to evaluate the effect of smoking on early mortality in HCC patients following curative treatment.

Methods

Data from the Korean Primary Liver Cancer Registry were examined for HCC patients who underwent liver resection or radiofrequency ablation between 2015 and 2018. Smoking cumulative dose was assessed in pack-years. The primary outcome was the 3-year overall survival (OS).

Results

Among 1,924 patients, 161 were classified as heavy smokers (≥40 pack-years). Heavy smokers exhibited a lower 3-year survival rate (77.1%) than nonsmokers (83.3%), with a significant difference observed

SUBMITTER: Lee J 

PROVIDER: S-EPMC11449571 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature