Recent update of proton beam therapy for hepatocellular carcinoma: a systematic review and meta-analysis.

ABSTRACT:

Backgrounds/aims

Although access to proton beam therapy (PBT) is limited worldwide, its use for the treatment of hepatocellular carcinoma (HCC) is gradually increasing with the expansion of new facilities. Therefore, we conducted a systematic review and metaanalysis to investigate the updated evidence of PBT for HCC.

Methods

The MEDLINE, EMBASE, Cochrane Library, and Web of Science databases were systematically searched for studies that enrolled patients with liver-confined HCC that were treated with PBT for a cure up to February 2024.

Results

A total of 1,858 HCC patients receiving PBT from 22 studies between 2004 and 2023 were selected for this meta-analysis. The median proportion of Child-Pugh class A was 86% (range, 41-100), and the median tumor size was 3.6 cm (r

SUBMITTER: Bae SH 

PROVIDER: S-EPMC11449586 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature