Relationships between regional burden of tau pathology and age at death and disease duration in PSP.

ABSTRACT:

Background

A definitive diagnosis of progressive supranuclear palsy (PSP) can only be established through neuropathological evaluations where four cardinal tau lesions are identified. Relationships between regional tau burden and disease duration/age at death is unclear.

Objective

To investigate relationships between tau burden in different brain regions and disease duration and age at death in PSP and determine whether association are influenced by PSP subtype (subcortical/cortical) or co-pathologies.

Methods

We identified 45 patients with definite PSP who were evaluated at Mayo Clinic between 2009 and 2023, died and underwent histopathological evaluation. We performed semi-quantitative lesion count for each of four cardinal lesions (pretangles/globose neurofibrillar

SUBMITTER: Badihian N 

PROVIDER: S-EPMC11449633 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature