Unveiling genetic links between gut microbiota and asthma: a Mendelian randomization.

ABSTRACT:

Background

Multiple studies suggest a potential connection between the gut microbiome and asthma. Our objective is to use advanced genetic and metagenomic techniques to elucidate the causal relationships and underlying mechanisms between gut microbiota and asthma.

Methods

The study utilized comprehensive Linkage Disequilibrium Score Regression (LDSC) and Mendelian randomization (MR) analyses to examine the relationship between 119 gut microbiota genera and asthma, using publicly accessible genome-wide association studies (GWAS). The meta-analysis synthesized summary effect estimates obtained from LDSC, forward MR, and reverse MR. The MiBioGen collaboration, involving 18,340 individuals, identified genetic variations associated with gut bacteria. Asthma data were collected fr

SUBMITTER: Zheng X 

PROVIDER: S-EPMC11449699 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature