Effects of two immunosuppression regimens on T-lymphocyte subsets in elderly kidney transplant recipients.

ABSTRACT:

Background

Despite the growing number of elderly kidney transplant (Ktx) recipients, few studies have examined the effects of immunosuppression on their lymphocyte profiles.

Methods

We evaluated the early conversion from mycophenolate sodium (MPS) to everolimus (EVL) after rabbit antithymocyte globulin (rATG) 2 mg/kg induction in elderly kidney recipients. Three groups of KTx patients were compared: (a) Young (n=20, 36 ± 7 y) receiving standard immunosuppression (Group A1) (prednisone, tacrolimus, and MPS), (b) Elderly (n=35, 65 ± 3 y) receiving standard immunosuppression (Group B1), and (c) Elderly (n=16, 65 ± 3 y) with early (mean 30 d) conversion from MPS to EVL (Group B2). Naive, memory, and regulatory peripheral blood TCD4⁺ lymphocytes were quantified at 0, 3

SUBMITTER: Freitas GRR 

PROVIDER: S-EPMC11449757 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature