Exploring the genetic etiology across the continuum of the general psychopathology factor: a Swedish population-based family and twin study.

ABSTRACT: Psychiatric comorbidity can be accounted for by a latent general psychopathology factor (p factor), which quantifies the variance that is shared to varying degrees by every dimension of psychopathology. It is unclear whether the entire continuum of the p factor shares the same genetic origin. We investigated whether mild, moderate, and extreme elevations on the p factor shared the same genetic etiology by, first, examining the linearity of the association between p factors across siblings (N = 580,891 pairs). Second, we estimated the group heritability in a twin sample (N = 17,170 pairs), which involves testing whether the same genetic variants influence both extreme and normal variations in the p factor. In both samples, the p factor was based on 10 register-based psychiatric diagnoses. R

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11449779 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature