Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia.

ABSTRACT: Schizophrenia (SCZ) is a neuropsychiatric disorder, caused by a combination of genetic and environmental factors. The etiology behind the disorder remains elusive although it is hypothesized to be associated with the aberrant response to neurotransmitters, such as dopamine and glutamate. Therefore, investigating the link between dysregulated metabolites and distorted neurodevelopment holds promise to offer valuable insights into the underlying mechanism of this complex disorder. In this study, we aimed to explore a presumed correlation between the transcriptome and the metabolome in a SCZ model based on patient-derived induced pluripotent stem cells (iPSCs). For this, iPSCs were differentiated towards cortical neurons and samples were collected longitudinally at various developmental stage

SUBMITTER: Spathopoulou A 

PROVIDER: S-EPMC11449784 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature