Gut microbiome predicts cognitive function and depressive symptoms in late life.

ABSTRACT: Depression in older adults with cognitive impairment increases progression to dementia. Microbiota is associated with current mood and cognition, but the extent to which it predicts future symptoms is unknown. In this work, we identified microbial features that reflect current and predict future cognitive and depressive symptoms. Clinical assessments and stool samples were collected from 268 participants with varying cognitive and depressive symptoms. Seventy participants underwent 2-year follow-up. Microbial community diversity, structure, and composition were assessed using high-resolution 16 S rRNA marker gene sequencing. We implemented linear regression to characterize the relationship between microbiome composition, current cognitive impairment, and depressive symptoms. We leveraged e

SUBMITTER: Kolobaric A 

PROVIDER: S-EPMC11449789 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature