The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression.

ABSTRACT: Reduced processing speed is a core deficit in major depressive disorder (MDD) and has been linked to altered structural brain network connectivity. Ample evidence highlights the involvement of genetic-immunological processes in MDD and specific depressive symptoms. Here, we extended these findings by examining associations between polygenic scores for tumor necrosis factor-α blood levels (TNF-α PGS), structural brain connectivity, and processing speed in a large sample of MDD patients. Processing speed performance of n = 284 acutely depressed, n = 177 partially and n = 198 fully remitted patients, and n = 743 healthy controls (HC) was estimated based on five neuropsychological tests. Network-based statistic was used to identify a brain network associated with processing speed. We employed

SUBMITTER: Flinkenflugel K 

PROVIDER: S-EPMC11449800 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature