The potential of x-ray virtual histology in the diagnosis of skin tumors.

ABSTRACT:

Background

Histopathological analysis represents the gold standard in clinical practice for diagnosing skin neoplasms. While the current diagnostic workflow has specialized in producing robust and accurate results, interpreting tissue architecture and malignant cellular morphology correctly remains one of the greatest challenges for pathologists. This paper aims to explore the prospect of applying x-ray virtual histology to human skin tumor excisions and correlating it with the histological validation.

Materials and methods

Seven skin biopsies containing intriguing melanoma types and pigmented skin lesions were scanned using x-ray Computed micro-Tomography (μCT) and then sectioned for conventional histology assessment.

Results

The tissue microarchitecture reconstructe

SUBMITTER: Saccomano G 

PROVIDER: S-EPMC11449805 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature