A New Tool to Identify Pediatric Patients with Atypical Diabetes Associated with Gene Polymorphisms.

ABSTRACT:

Backgruound

Recent diabetes subclassifications have improved the differentiation between patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus despite several overlapping features, yet without considering genetic forms of diabetes. We sought to facilitate the identification of monogenic diabetes by creating a new tool that we validated in a pediatric maturity-onset diabetes of the young (MODY) cohort.

Methods

We first created the DIAgnose MOnogenic DIAbetes (DIAMODIA) criteria based on the pre-existing, but incomplete, MODY calculator. This new score is composed of four strong and five weak criteria, with patients having to display at least one weak and one strong criterion.

Results

The effectiveness of the DIAMODIA criteria was evaluated in two p

SUBMITTER: Welsch S 

PROVIDER: S-EPMC11449816 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature