Causal relationship between green tea intake and gastrointestinal disorders: a two-sample Mendelian randomization study.

ABSTRACT:

Background

The precise association between green tea intake and gastrointestinal disorders remains controversial. This study aimed to investigate the potential causal association between green tea intake and gastrointestinal disorders through a two-sample Mendelian randomization (MR) study.

Methods

Utilizing publicly accessible data from genome-wide association studies (GWAS), we identified SNPs strongly linked with the study variables from multiple large databases to serve as instrumental variables (IVs). MR analyses were executed utilizing the inverse variance weighting (IVW) method, with the resultant effect estimates serving as the primary outcome measure. In addition, a multivariate MR design was performed to adjust for smoking and alcohol consumption. To ensure the rob

SUBMITTER: Chen C 

PROVIDER: S-EPMC11449853 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature