Photobiomodulation regulates astrocyte activity and ameliorates scopolamine-induced cognitive behavioral decline.

ABSTRACT:

Introduction

The pathophysiological mechanism of Alzheimer's disease (AD) has not been clearly identified, and effective treatment methods have not yet been established. Scopolamine causes cholinergic dysfunction in the brain, including the accumulation of amyloid-beta plaques, thereby increasing oxidative stress and neuroinflammation, mimicking AD. Glial cells such as astrocytes have recently been identified as possible biomarkers for AD. Photobiomodulation (PBM) elicits a beneficial biological response in cells and tissues. PBM effects on the central nervous system (CNS) have been widely researched, including effects on astrocyte activity.

Methods

In the present study, PBM was performed using light at the near-infrared wavelength of 825 nm. The Morris water maze and Y-maze

SUBMITTER: Park JO 

PROVIDER: S-EPMC11449862 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature