A dietary intervention with conjugated linoleic acid enhances microstructural white matter reorganization in experimental stroke.

ABSTRACT:

Background

A dietary supplementation with conjugated linoleic acid (CLA) was shown to attenuate inflammation and increase the proportions of circulating regulatory T cells (T_regs) and M2-type macrophages in disease models such as autoimmune encephalitis and arteriosclerosis. Since T_regs and anti-inflammatory (M2-type) macrophages were found to enhance stroke recovery, we hypothesized that CLA-supplementation might improve stroke recovery via immune modulatory effects.

Methods

Functional assessment was performed over 90 days after induction of experimental photothrombotic stroke in wild type mice (n = 37, sham n = 10). Subsequently, immunological characterization of different immunological compartments (n = 16), ex vivo magnet

SUBMITTER: Straeten FA 

PROVIDER: S-EPMC11449868 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature