Spontaneous Calcium Transients Recorded from Striatal Astrocytes in a Preclinical Model of Autism.

ABSTRACT: Autism spectrum disorder (ASD) is known as a group of neurodevelopmental conditions including stereotyped and repetitive behaviors, besides social and sensorimotor deficits. Anatomical and functional evidence indicates atypical maturation of the striatum. Astrocytes regulate the maturation and plasticity of synaptic circuits, and impaired calcium signaling is associated with repetitive behaviors and atypical social interaction. Spontaneous calcium transients (SCT) recorded in the striatal astrocytes of the rat were investigated in the preclinical model of ASD by prenatal exposure to valproic acid (VPA). Our results showed sensorimotor delay, augmented glial fibrillary acidic protein -a typical intermediate filament protein expressed by astrocytes- and diminished expression of GABA_A

SUBMITTER: Saavedra-Bonilla H 

PROVIDER: S-EPMC11450070 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature