The MyoGravity project to study real microgravity effects on human muscle precursor cells and tissue.

ABSTRACT: Microgravity (µG) experienced during space flights promotes adaptation in several astronauts' organs and tissues, with skeletal muscles being the most affected. In response to reduced gravitational loading, muscles (especially, lower limb and antigravity muscles) undergo progressive mass loss and alteration in metabolism, myofiber size, and composition. Skeletal muscle precursor cells (MPCs), also known as satellite cells, are responsible for the growth and maintenance of muscle mass in adult life as well as for muscle regeneration following damage and may have a major role in µG-induced muscle wasting. Despite the great relevance for astronaut health, very few data are available about the effects of real µG on human muscles. Based on the MyoGravity project, this study aimed to analyze: (i

SUBMITTER: Di Filippo ES 

PROVIDER: S-EPMC11450100 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature