Lymphatic-specific methyltransferase-like 3-mediated m⁶A modification drives vascular patterning through prostaglandin metabolism reprogramming.

ABSTRACT: Lymphangiogenesis plays a pivotal role in the pathogenesis of various vascular disorders, including ocular vascular diseases and cancers. Deregulation of N ⁶-methyladenosine (m⁶A) modification has been identified as a key contributor to human diseases. However, the specific involvement of m⁶A modification in lymphatic remodeling remains poorly understood. In this study, we demonstrate that inflammatory stimulation and corneal sutures induce elevated levels of methyltransferase-like 3 (METTL3)-mediated m⁶A modification. METTL3 knockdown inhibits lymphatic endothelial viability, proliferation, migration, and tube formation in vitro. METTL3 knockdown attenuates corneal sutures-induced lymphangiogenesis and intratumoral lymphangiogenesis initi

SUBMITTER: Shi L 

PROVIDER: S-EPMC11450254 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature