Does LDL-C determination method affect statin prescribing for primary prevention? A register-based study in Southern Denmark.

ABSTRACT:

Aims

Examine whether the low-density lipoprotein cholesterol (LDL -C) determination method influences the rate of statin initiation for primary prevention of cardiovascular disease.

Methods and results

We conducted a register-based retrospective study in the Region of Southern Denmark. Two hospital-based laboratories in the region directly measure LDL -C whereas four laboratories calculate LDL -C using Friedewald's formula. Physicians do not choose which method is used. We included all statin-naïve patients ≥40 years with no history of cardiovascular disease, diabetes, or chronic kidney disease, who had their LDL -C determined during 2018-2019. There were 202 807 people who had LDL -C determined during the study period (median age 59 years, 44% women) of which 37% had a dire

SUBMITTER: Pottegard A 

PROVIDER: S-EPMC11450267 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature