Kinetics of Viral Shedding for Outbreak Surveillance of Emerging Infectious Diseases: Modeling Approach to SARS-CoV-2 Alpha and Omicron Infection.

ABSTRACT:

Background

Previous studies have highlighted the importance of viral shedding using cycle threshold (Ct) values obtained via reverse transcription polymerase chain reaction to understand the epidemic trajectories of SARS-CoV-2 infections. However, it is rare to elucidate the transition kinetics of Ct values from the asymptomatic or presymptomatic phase to the symptomatic phase before recovery using individual repeated Ct values.

Objective

This study proposes a novel Ct-enshrined compartment model to provide a series of quantitative measures for delineating the full trajectories of the dynamics of viral load from infection until recovery.

Methods

This Ct-enshrined compartment model was constructed by leveraging Ct-classified states within and between presymptomatic and

SUBMITTER: Lin TY 

PROVIDER: S-EPMC11450350 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature