Causal association between metabolites and upper gastrointestinal tumors: A Mendelian randomization study.

ABSTRACT: Upper gastrointestinal (UGI) tumors, notably gastric cancer (GC) and esophageal cancer (EC), are significant global health concerns due to their high morbidity and mortality rates. However, only a limited number of metabolites have been identified as biomarkers for these cancers. To explore the association between metabolites and UGI tumors, the present study conducted a comprehensive two‑sample Mendelian randomization (MR) analysis using publicly available genetic data. In the present study, the causal relationships were examined between 1,400 metabolites and UGI cancer using methods such as inverse variance weighting and weighted medians, along with sensitivity analyses for heterogeneity and pleiotropy. Functional experiments were conducted to validate the MR results. The analysis identi

SUBMITTER: Nov P 

PROVIDER: S-EPMC11450430 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature