Efficacy and safety of patent foramen ovale closure for mitigating migraine: a systematic review and meta-analysis of randomized trials and observational studies.

ABSTRACT:

Background

Although often asymptomatic, patent foramen ovale (PFO) may cause disabling migraine symptoms. Evidence regarding PFO closure for prevention of migraine is still ambiguous and conflicting.

Objectives

This study aims to analyze the efficacy and safety of PFO closure for mitigating migraine symptoms.

Design

This is a systematic review and meta-analysis of randomized clinical trials (RCTs) and observational studies.

Data sources and methods

A comprehensive search was conducted on the Scopus, Medline, ClinicalTrials.gov, and Cochrane Library databases up until March 12, 2024. This review incorporates literature that examines the comparison between PFO closure and control with outcome data related to migraine. We employed random-effect models to analyze t

SUBMITTER: Silalahi TDA 

PROVIDER: S-EPMC11450578 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature